Media reports | stem cell clinical application case

Stem cell therapy, as the most promising treatment in regenerative medicine, is widely used in the treatment of various diseases. Many patients with refractory diseases have benefited from stem cell therapy. Today, we will take a look at some cases of stem cell therapy:

1. The first treatment of lupus erythematosus with mesenchymal stem cells in Hunan

Two patients with refractory systemic lupus erythematosus (SLE) were successfully transplanted with umbilical cord blood mesenchymal stem cells in the Department of Rheumatology and immunology of the Second Xiangya Hospital, and the expected results were achieved. It is the first time that this technique has been used in the treatment of refractory systemic lupus erythematosus in Hunan.


2. The first case of treating cerebral palsy with autologous cord blood in Shenzhen

The premature baby, Le Le (not her real name), was diagnosed with cerebral palsy after a detailed examination when she was 3 months old. Subsequently, the child completed autologous umbilical cord blood transplantation in the Hematology and Oncology Department of Shenzhen Children's Hospital. This is the first case of autologous umbilical cord blood transfusion in a child with cerebral palsy in Shenzhen. After treatment, the child's muscle tension has been relieved and gross motor development has improved significantly.


3. The world's first placental stem cell treatment for anemia of regenerative disorder
In 2013, a 9-year-old rural girl from Qian 'an, Hebei province was treated at the 307th Hospital of the People's Liberation Army for anemia caused by reproductive disorder. In March 2014, after obtaining the consent of the child's parents, 307 Hospital extracted hematopoietic stem cells combined with umbilical cord hematopoietic stem cells from the placenta of the girl's newborn sister for transplantation treatment. The child was discharged from hospital after recovery, and now the hematopoietic function has returned to normal and the health condition is stable. This is also the world's first successful transplantation of placental hematopoietic stem cells combined with umbilical cord hematopoietic stem cells in the treatment of severe anemia with regenerative disorders.


4. The world's first treatment of children with leukemia with autologous cord blood
For the first time, an Illinois hospital has successfully treated a child with acute lymphoblastic leukemia (ALL) with an autologous cord blood transplant. Age 3, was diagnosed with leukemia children hospital, first take the chemotherapy, after remission in the central nervous system relapse, through systematic chemotherapy at all expect a second relief, in 2006, the doctor for her until her parents when she was born to infusion preserved for her umbilical cord blood, four months later, her blood count returned to normal, and a year later, Bone marrow examination showed normal hematopoiesis and good health.


5. The world's first baby born from stem cell repair of ovaries
Ms. Fang was diagnosed with premature ovarian failure by many hospitals, and went to many major hospitals across the country to seek medical treatment in vain. In December 2015, the clinical team of Professor Sun Haixiang of Nanjing Drum Tower Hospital carried out the first intraovarian stem cell transplantation for Ms. Fang. Postoperative reexamination showed that Ms Fang's ovarian blood flow had significantly improved. In 2016, Fang underwent two more stem cell transplants. In May 2017, it was confirmed that Fang's ovarian function had largely recovered and she had a natural pregnancy that month. A 34-year-old woman surnamed Fang gave birth to a healthy baby boy weighing 2.97 kg at 9:20 am on January 12, 2018. This is the first time in the world that stem cells have been used to repair a woman's premature ovarian failure to conceive a healthy baby.


6. The world's first stem cell treatment for meniscus injury
The Department of Rehabilitation Medicine of Tongji Hospital successfully carried out the world's first minimally invasive treatment of meniscus injury with functional cells differentiated from human embryonic stem cells for a patient with knee joint injury. After treatment, the patient could walk normally and go up and down stairs. This method is expected to be used in the treatment of diabetic foot and knee degenerative diseases in the future.


7. There have been 2 cases in the world where stem cell transplantation has cured AIDS
In March 2019, scientists confirmed that a London man may have been successfully cured of AIDS after receiving a stem cell transplant. It is the second HIV case in the world after a patient in Berlin, Germany, was cleared of the disease in 2007. Both patients had both HIV and cancer, and both were treated with stem cells from donors with mutations in the CCR5 gene.


Stem cell technology has brought medical treatment into a whole new cellular era. With the in-depth research of stem cells in the scientific community, stem cells will have a greater role in the treatment of diseases and health care in the future!